This publication is the first in a series dedicated to prevalent illicit synthetic stimulant drugs, also known as amphetamine-type stimulants (ATS). The ATS category is made up of two groups of substances. This study focuses on the supply and use of methamphetamine in Europe, set in a global context. Methamphetamine is probably the most widely consumed synthetic stimulant in the world. In many countries across the globe it is reportedly the second most prevalent illicit drug after cannabis.